CELL-SHAPE CHANGES AND DETACHMENT IN CELL-CULTURE - MODELS OF RENAL INJURY

Loss of tubular cell adhesion may be important in the pathophysiology of injury to renal tubular cell epithelium. In-vitro model systems hav e been utilized to examine altered cell adhesion in response to hypoxi c/anoxic and oxidant-induced cell injury. Alterations in cell cytoskel eton and cell surface adhesion molecules, including L-CAM and integrin s, have been demonstrated in these systems, and are probably important in the pathogenesis of altered structure and function in response to injury in renal tubular epithelium.