SPIRADENOCARCINOMA - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF 3 CASES

Three cases of malignant transformation within spiradenoma are describ ed. All of them occurred close to the elbow. In every case we found a benign component, characteristic of the spiradenoma, and a structure o f carcinoma, which in some areas showed transition into the spiradenom a. In one case the structure of the spiradenocarcinoma resembled that of the spiradenoma, whereas in the remaining two cases adenocarcinoma was the malignant counterpart of the tumor. We performed immunohistoch emical studies and revealed various intensities of expression of cytok eratins and epithelial membrane antigen and a dearth of S-100 protein, vimentin, and carcinoembryonic antigen in the examined cases of spira denocarcinoma.