STRUCTURE-ACTIVITY-RELATIONSHIPS FOR RELAXATION OF SMOOTH-MUSCLE BY VIP

Authors
SHIRAHASE H COY DH RORSTAD OP
Citation
H. Shirahase et al., STRUCTURE-ACTIVITY-RELATIONSHIPS FOR RELAXATION OF SMOOTH-MUSCLE BY VIP, Peptides, 15(2), 1994, pp. 383-385
Citations number
6
Categorie Soggetti
Biology
Journal title
Peptides → ACNP
ISSN journal
01969781
Volume
15
Issue
2
Year of publication
1994
Pages
383 - 385
Database
ISI
SICI code
0196-9781(1994)15:2<383:SFROSB>2.0.ZU;2-O
Abstract
Utilizing VIP and five VIP analogues, concentration-response curves fo r relaxation of rat mesenteric artery and rat gastric longitudinal mus cle were determined for comparison with our previously published radio ligand binding data on rat smooth muscle and other tissues. The biolog ical potency of the VIP analogues in the present study compared more c losely with their potency for VIP receptor binding in smooth muscle ti ssue (arteries) vs. other tissues (pituitary, brain, liver).