The results of Interferon-gamma therapy for systemic sclerosis (SSc) a
re reported in this paper. 25 patients were evaluated after a median f
ollow up of three and a half years and a significant improvement of th
e skin score could be demonstrated in early forms of SSc. Visceral man
ifestations of SSc did not improve in general, whereas individual pati
ents also benefited from therapy. Interferon-gamma therapy was general
ly well tolerated, only flue-like symptoms occured.