ENDOGENOUS ENDOPHTHALMITIS DUE TO FUSARIUM - CASE-REPORT AND REVIEW

Endogenous fungal endophthalmitis is being increasingly recognized in susceptible individuals. We report a case of endogenous endophthalmiti s due to Fusarium solani that occurred as the sole clinical manifestat ion of fungal disease in an immunocompromised host. Four previously re ported cases of endogenous fusarial endophthalmitis are also reviewed. Two of these patients had no underlying disease and presented with is olated endophthalmitis, while two other patients had acute leukemia an d presented with multiple organ involvement due to Fusarium. All three patients with leukemia, including our patient, were severely neutrope nic at the time of diagnosis. Two of these three patients had fungemia . MICs of amphotericin B for fungal isolates ranged from 0.14 to 10 mu g/mL. Despite abatement of the endophthalmitis after antifungal therap y and vitrectomy, the prognosis for immunocompromised patients remains guarded because of underlying disease.