M. Bergmann et al., INTRAVASCULAR LYMPHOMATOSIS OF THE CNS - CLINICOPATHOLOGICAL STUDY AND SEARCH FOR EXPRESSION OF ONCOPROTEINS AND EPSTEIN-BARR-VIRUS, Clinical neurology and neurosurgery, 96(3), 1994, pp. 236-243
Five cases of intravascular lymphomatosis (IVL) are reported. Diffuse
or focal cerebral signs suggestive of vascular disease occurred in fou
r cases. but case 5 presented with symptoms similar to Creutzfeld-Jako
b disease. Clinical course ranged from two to eight months and diagnos
is was made in all cases by autopsy. Neoplastic lymphoid cells mainly
lodged in lumina of small vessels in many organs, but infarction was c
onfined to the CNS. Some extravascular tumor cells were regularly seen
. All cases corresponded to high-grade Non-Hodgkin lymphomas of B-cell
type and displayed high proliferation indices. Different from finding
s in primary cerebral and nodal lymphomas, neither p53 nor bcl-2 oncop
roteins were detectable. Absence of EBV genome and EBV latent membrane
protein from IVL was demonstrated for the first time.