A 9-year old male Arabian horse was referred to the Department of Larg
e Animal Surgery of the University of Utrecht because of multiple nodu
les on the inner side of the right hind leg. The nodules seemed to fol
low a cutaneolymphatic pattern. Histopathology of a nodule showed a gr
anulomatous inflammation with the presence of multinucleated giant cel
ls. In PAS- and Grocott-stained sections, spheroid yeast-like organism
s with some budding were found throughout the tissue. A preliminary di
agnosis of sporotrichosis was made. A fresh nodule was cultured and th
e presence of Sporothrix c.f. schenckii was confirmed. Antifungal ther
apy was started, which stopped the extension of the granulomata. Sporo
trichosis is a rare disease in Europe, but it is quite common in the s
outhern part of the U.S.A.