ADOPTIVE TRANSFER OF IMMUNITY IN SENSITIZED SPLEEN-CELLS COLLECTED FROM EXPERIMENTALLY PRODUCED SARCOMAS IN MICE

The adoptive transfer of immunity to a chemically induced sarcoma was accomplished by mixing the sensitized spleen cells with tumour cells a nd injecting them subcutaneous in mice. Spleen cells utilized on 8th, 12th and 20th and 40th day after surgical removal of tumour proved to be most effective in transferring immunity and thereafter effect decli ned. Spleen cells utilized within 2 hr after amputation of tumour prov ed ineffective. Spleen cells collated from hyper-immunized mice were n ot effective in adoptive transfer of immunity although there was an in crease in the latent and survival period. The above observations indic ate that the tumour bearing animals remained in a partially tolerant s tate, which disappears between 8th to 20th day after surgical removal of tumour. It also demonstrate that cell to cell contact is essential for the success of adoptive immunity against tumour.