EFFECTS OF ADRENOCEPTOR ANTAGONISTS ON THE HYPERTHERMIA AND HYPERGLYCEMIA-INDUCED BY PROSTAGLANDIN-F2-ALPHA IN RATS

We investigated the effects of intraperitoneal administration of adren oceptor antagonists on the hyperthermia and hyperglycemia induced by p rostaglandin F-2 alpha (50 mu g) injected into the third cerebral vent ricle in anesthetized rats. Phentolamine inhibited the hyperthermia an d hyperglycemia induced by prostaglandin F-2 alpha. Prazosin inhibited the hyperthermia induced by prostaglandin F-2 alpha, while enhancing the hyperglycemia. Yohimbine inhibited the prostaglandin F-2 alpha-ind uced hyperglycemia without an effect on the hyperthermia. Propranolol had no effect on either prostaglandin F-2 alpha-induced hyperglycemia or hyperthermia. These observations suggest that the hyperglycemia ind uced by prostaglandin F-2 alpha is regulated by alpha(2)-adrenoceptor systems while the hyperthermia is regulated by alpha(1)-adrenoceptor s ystems in rats.