T. Arrigo et al., ADULT HEIGHT EXCEEDING TARGET HEIGHT IN A PATIENT WITH CONGENITAL PANHYPOPITUITARISM DIAGNOSED AFTER THE AGE OF 25 YEARS, Journal of pediatric endocrinology, 7(3), 1994, pp. 269-272
This case report concerns a prepubertal patient (height 148.7 cm) with
congenital anterior panhypopituitarism diagnosed at the chronological
age of 25.2 years (bone age 12.5). In spite of his advanced age on in
itiation of hormonal replacement therapy this patient achieved an adul
t height (172.8 cm), exceeding those of his father and brothers, becau
se of his markedly delayed bone age. This satisfactory height outcome
confirms that final height in hypopituitarism depends on both height a
t onset of puberty and height with respect to bone age but not chronol
ogical age at initiation of growth hormone treatment.