KARYOTYPE EVOLUTION IN A PATIENT WITH DOWN-SYNDROME AND ACUTE-LEUKEMIA FOLLOWING A CONGENITAL LEUKEMOID REACTION

We report the serial cytogenetic study of a patient with Down syndrome who experienced a congenital leukemoid reaction, underwent a spontane ous remission within four months, and subsequently developed acute mye loid leukemia at 16 months. A blood chromosome study to rule out Down syndrome performed at age 24 days, during the leukemoid reaction, reve aled a 47,XX,+21 karyotype. The diagnosis of acute leukemia was made a t 16 months, at which time a chromosome study, on bone marrow, was per formed. This analysis revealed a clonal karyotype of 47,XX,+21,-22,+de r (22)t(1;22)(q21;q13) in all but one cell studied. The single apparen tly nonclonal cell showed a karyotype of 49,XX,+12,-13,-19, +der(19)t( 19;?)(q11;?)x2,+21,+22. A third chromosome study at 19 months indicate d the original leukemic clone with t(1;22) (q21;q13) had been replaced by the clone represented by the single cell with 49 chromosomes seen in the previous chromosome study. This case of an infant with Down syn drome and acute leukemia illustrated rapid evolution and a transitory nature to clonal chromosome aberrations while retaining AML morphology and course. (C) 1994 Wiiey-Liss, Inc.