EFFECT OF ADMINISTRATION OF 3-ACETYLPYRIDINE FOLLOWED BY NIACINAMIDE INJECTION ON SURVIVAL, EXTENT OF THE INFERIOR OLIVARY COMPLEX LESION, AND RESPONSE TO HARMALINE IN THE YOUNG-RAT
N. Jones et al., EFFECT OF ADMINISTRATION OF 3-ACETYLPYRIDINE FOLLOWED BY NIACINAMIDE INJECTION ON SURVIVAL, EXTENT OF THE INFERIOR OLIVARY COMPLEX LESION, AND RESPONSE TO HARMALINE IN THE YOUNG-RAT, Brain research, 656(2), 1994, pp. 257-262
In the 15 day-old DA/HAN strained rat, i.p. injection of 3-acetylpyrid
ine (3-AP) 50, 65 or 95 mg.kg(-1) was followed 2 to 4 hours later by a
dministration of niacinamide (300 mg.kg(-1)). The percentage of surviv
al and the extent of the inferior olivary complex (IOC) lesion, determ
ined histologically, were correlated with both the dose of 3-AP admini
stered and the time delay between 3-AP and niacinamide injections. Mor
eover, the tremor elicited by harmaline was also correlated with the e
xtent of the IOC lesion. The results show that it is more advantageous
to administer 95 mg.kg(-1) 3-AP and to delay niacinamide injection by
2h30 or less to get the higher percentage of survival (about 90%) and
a reasonably high percentage of totally IOC lesioned rats (more than
30%). They also demonstrate that the harmaline test is not sufficient
to acutely judge of the extent of the IOC lesion and that, in all case
s, histological controls have to be done. The results are discussed in
terms of interrelationships of the variable studied.