ACYCLIC NK-1 ANTAGONISTS - 2-BENZHYDRYL-2-AMINOETHYL ETHERS

Authors
WILLIAMS BJ TEALL M MCKENNA J HARRISON T SWAIN CJ CASCIERI MA SADOWSKI S STRADER C BAKER R
Citation
Bj. Williams et al., ACYCLIC NK-1 ANTAGONISTS - 2-BENZHYDRYL-2-AMINOETHYL ETHERS, Bioorganic & medicinal chemistry letters, 4(16), 1994, pp. 1903-1908
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
16
Year of publication
1994
Pages
1903 - 1908
Database
ISI
SICI code
0960-894X(1994)4:16<1903:ANA-2E>2.0.ZU;2-M
Abstract
A series of 2-aminoethyl ethers based on diphenylalaninol have been sh own to have significant affinity for the human NK1 receptor and reduce d affinity at the L-type Ca++ channel compared with quinuclidines rela ted to CP 96,345.