SYNTHESIS OF AN ARABINONUCLEIC ACID (TANA)

Authors
RESMINI M PFLEIDERER W
Citation
M. Resmini et W. Pfleiderer, SYNTHESIS OF AN ARABINONUCLEIC ACID (TANA), Bioorganic & medicinal chemistry letters, 4(16), 1994, pp. 1909-1912
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
16
Year of publication
1994
Pages
1909 - 1912
Database
ISI
SICI code
0960-894X(1994)4:16<1909:SOAAA(>2.0.ZU;2-#
Abstract
The introduction of the p-nitrophenylethyl- (NPE) and p-nitrophenyleth oxycarbonyl- (NPEOC) group for amino and hydroxy protection of purine and pyrimidine arabinofuranosides and their interconversion into the c orresponding 3'-phosphoramidite building blocks provided very effectiv e starting materials for solid support oligoarabinonucleotide synthese s. A structural analogue of the Phage T5 histidine tRNA consisting of 78 nucleotide units has been synthesized in excellent yield and high p urity.