AMSELAMINE, A NEW SELECTIVE HISTAMINE H-2-RECEPTOR AGONIST

Authors
VANDERGOOT H ERIKS JC LEURS R TIMMERMAN H
Citation
H. Vandergoot et al., AMSELAMINE, A NEW SELECTIVE HISTAMINE H-2-RECEPTOR AGONIST, Bioorganic & medicinal chemistry letters, 4(16), 1994, pp. 1913-1916
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
16
Year of publication
1994
Pages
1913 - 1916
Database
ISI
SICI code
0960-894X(1994)4:16<1913:AANSHH>2.0.ZU;2-8
Abstract
The synthesis of amselamine (2-amino-5-(2-aminoethyl)-4-methyl- 1,3-se lenazole), a potent histamine H-2-agonist, has been described. At the guinea pig right atrium amselamine revealed to be slightly more active than Its sulfur analogue amthamine and histamine. Moreover negligible effects on H-1 and H-3-receptors were observed.