SYNTHESIS AND IN-VITRO CYTOTOXICITY OF DIASTEREOISOMERICALLY MODIFIEDDOLASTATIN-15 ANALOGS

Authors
ROUX F GALEOTTI N PONCET J JOUIN P CROS S ZENKE G
Citation
F. Roux et al., SYNTHESIS AND IN-VITRO CYTOTOXICITY OF DIASTEREOISOMERICALLY MODIFIEDDOLASTATIN-15 ANALOGS, Bioorganic & medicinal chemistry letters, 4(16), 1994, pp. 1947-1950
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
16
Year of publication
1994
Pages
1947 - 1950
Database
ISI
SICI code
0960-894X(1994)4:16<1947:SAICOD>2.0.ZU;2-Z
Abstract
Dolastatin 15 1(4S,7S) is a potent cytostatic depsipeptide of marine o rigin. Analysis of the effects of the stereochemistry in the non-pepti de moiety on activity revealed that chirality inversion in the aromati c terminal region preserves the antiproliferative activity.