IDENTIFICATION AND CHARACTERIZATION OF THE ISOMERS OF CYCLOTHIAZIDE RESPONSIBLE FOR POTENTIATING AMPA CURRENT

Authors
CORDI AA SERKIZ B HENNIG P MAHIEU JP BOBICHON C DENANTEUIL G LEPAGNOL JM
Citation
Aa. Cordi et al., IDENTIFICATION AND CHARACTERIZATION OF THE ISOMERS OF CYCLOTHIAZIDE RESPONSIBLE FOR POTENTIATING AMPA CURRENT, Bioorganic & medicinal chemistry letters, 4(16), 1994, pp. 1957-1960
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
16
Year of publication
1994
Pages
1957 - 1960
Database
ISI
SICI code
0960-894X(1994)4:16<1957:IACOTI>2.0.ZU;2-T
Abstract
The four diastereoisomers of cyclothiazide have been separated by chro matography. The most potent fraction was split further into two enanti omers by chiral HPLC. The most active isomer is five times more potent than cyclothiazide in potentiating AMPA transmission in rat cortex mR NA injected Xenopus oocytes.