MINIGLUCAGON PRODUCTION FROM GLUCAGON - AN EXTRACELLULAR PROCESSING OF A HORMONE USED AS A PROHORMONE

Authors
BLACHE P KERVRAN A LENGUYEN D BATAILLE D
Citation
P. Blache et al., MINIGLUCAGON PRODUCTION FROM GLUCAGON - AN EXTRACELLULAR PROCESSING OF A HORMONE USED AS A PROHORMONE, Biochimie, 76(3-4), 1994, pp. 295-299
Citations number
23
Categorie Soggetti
Biology
Journal title
Biochimie → ACNP
ISSN journal
03009084
Volume
76
Issue
3-4
Year of publication
1994
Pages
295 - 299
Database
ISI
SICI code
0300-9084(1994)76:3-4<295:MPFG-A>2.0.ZU;2-V
Abstract
Glucagon is secondarily processed into its C-terminal (19-29) fragment , referred to as 'miniglucagon', which modulates the glucagon action. This extracellular processing, occurring at the level of the glucagon target cells, is due to the presence at the cell surface of a new 100- kDa processing enzyme with characteristics of both thiol- and metallop rotease.