SWISS POPULATION-DATA ON 3 TETRAMERIC SHORT TANDEM REPEAT LOCI - VWA,HUMTHO1, AND F13A1 - DERIVED USING MULTIPLEX PCR AND LASER FLUORESCENCE DETECTION

Allele and genotype frequencies for 3 tetrameric short tandem repeat l oci VWA, HUMTHO1, and F13A1 were determined in a Swiss population samp le using multiplex PCR and subsequent electrophoresis in DNA sequencin g gels processed by automated laser fluorescence detection. The techni que allows single base pair resolution and rapid typing, with a concom itant reduction in the potential for human transcriptional typing erro rs. All loci meet Hardy-Weinberg expectations. In addition, there is l ittle evidence for association of alleles among the 3 loci. The alleli c frequency data can be used in forensic analyses and paternity tests to estimate the frequency of a multiple STR locus DNA profile in the S wiss population.