SUPEROXIDE-DISMUTASE INHIBITS INTERLEUKIN-1-INDUCED DEGRADATION OF HUMAN CARTILAGE

Authors
FUKUDA K DAN H SAITOH M TAKAYAMA M TANAKA S
Citation
K. Fukuda et al., SUPEROXIDE-DISMUTASE INHIBITS INTERLEUKIN-1-INDUCED DEGRADATION OF HUMAN CARTILAGE, Agents and actions, 42(1-2), 1994, pp. 71-73
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Agents and actions → ACNP
ISSN journal
00654299
Volume
42
Issue
1-2
Year of publication
1994
Pages
71 - 73
Database
ISI
SICI code
0065-4299(1994)42:1-2<71:SIIDOH>2.0.ZU;2-U
Abstract
Interleukin-1 (IL-1) is a key mediator in the pathogenesis of cartilag e destruction in arthritis-related disorders. Human recombinant supero xide dismutase (SOD) blocked IL-1-mediated cartilage destruction but h ad no effect on IL-1-mediated changes in glycosaminoglycan and prostag landin E2 synthesis. These data suggest that superoxide anions may be one factor of IL-1-mediated cartilage destruction.