MULTIPLE FOLLICULAR DEVELOPMENT ASSOCIATED WITH HERBAL MEDICINE

After three endocrinologically normal cycles while undergoing unstimul ated in-vitro fertilization treatment, a woman took a herbal medicine (Vitex agnus castus) at the beginning of a fourth unstimulated IVF tre atment cycle. In this fourth cycle, her serum gonadotrophin and ovaria n hormone measurements were disordered. One embryo resulted from the t hree eggs collected but a pregnancy did not ensue. She had symptoms su ggestive of mild ovarian hyperstimulation syndrome in the luteal phase . Two subsequent cycles were endocrinologically normal. We do not advo cate the use of this herbal medicine to promote normal ovarian functio n.