INTERFERENCE WITH THE FUNCTION OF LEUKOCYTE ADHESION MOLECULES BY MONOCLONAL-ANTIBODIES - A NEW APPROACH TO BURN INJURY

Authors
MILESKI WJ ROTHLIEN R LIPSKY P
Citation
Wj. Mileski et al., INTERFERENCE WITH THE FUNCTION OF LEUKOCYTE ADHESION MOLECULES BY MONOCLONAL-ANTIBODIES - A NEW APPROACH TO BURN INJURY, European journal of pediatric surgery, 4(4), 1994, pp. 225-230
Citations number
39
Categorie Soggetti
Surgery,Pediatrics
Journal title
European journal of pediatric surgery → ACNP
ISSN journal
09397248
Volume
4
Issue
4
Year of publication
1994
Pages
225 - 230
Database
ISI
SICI code
0939-7248(1994)4:4<225:IWTFOL>2.0.ZU;2-U
Abstract
Monoclonal antibody to intercellular adherence molecule-1 (ICAM-1) was used to inhibit leukocyte adherence in two models of burn injury. The antibodies to ICAM-1 had significant effects in preserving microvascu lar blood Bow in burn wounds, and in modulating the systemic response to major burn injury. These results suggest a central role for leukocy tes in the pathophysiologic response to burn injury.