THE ROLE OF 5-HT1A SEROTONIN AND D-2 DOPAMINE-RECEPTORS IN BUSPIRONE EFFECTS ON CORTICAL ELECTRICAL-ACTIVITY IN RATS

The effects of buspirone (5 and 10 mg/kg i.p.), 8-OH-DPAT (0.25 mg/kg) and raclopride (2.5 mg/kg) on the EEG power spectra of the sensorimot or cortex were studied in freely moving rats. Buspirone (5 mg/kg) and 8-OH-DPAT produced selective slowing of the theta-activity. Buspirone (10 mg/kg) produced slowing of the theta-activity and increased the po wer of the alpha-band (9-11 Hz). Raclopride alone did not influence EE G power spectra. Simultaneous injection of 8-OH-DPAT and raclopride pr oduced marked slowing of the theta-activity and increased the power of the alpha-band. The role of 5 HT1A and D-2 dopamine receptors in busp irone effects on cortical electrical activity in rats was discussed.