EXTRACELLULAR LEVELS OF SEROTONIN IN THE MEDIAL PONTINE RETICULAR-FORMATION IN ACUTE DECEREBRATE CATS WITH A MICRODIALYSIS TECHNIQUE

Authors
IWAKIRI H TAKAKUSAKI K NONAKA S MORI S
Citation
H. Iwakiri et al., EXTRACELLULAR LEVELS OF SEROTONIN IN THE MEDIAL PONTINE RETICULAR-FORMATION IN ACUTE DECEREBRATE CATS WITH A MICRODIALYSIS TECHNIQUE, Neuroscience letters, 177(1-2), 1994, pp. 19-22
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
177
Issue
1-2
Year of publication
1994
Pages
19 - 22
Database
ISI
SICI code
0304-3940(1994)177:1-2<19:ELOSIT>2.0.ZU;2-R
Abstract
Extracellular levels of serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) were measured in the medial pontine reticular formation of a cute decerebrate cats. The mean basal levels of 5-HT and 5-HIAA were 2 6 fmol/20 mu l and 15 pmol/20 mu l. Perfusion of the dialysis probe wi th high K+ and Ca2+-free Ringer solution for 60 min resulted in 4.8-8. 5 x increase and 25-48% decrease in the extracellular levels of 5-HT, respectively, in comparison to the basal 5-HT levels. Perfusion with T TX-added Rinaer solution for 60 min resulted in a consistent decrease in the extracellular levels of 5-HT.