DEMONSTRATION OF CRP IMMUNOREACTIVITY IN BRAINS OF ALZHEIMERS-DISEASE- IMMUNOHISTOCHEMICAL STUDY USING FORMIC-ACID PRETREATMENT OF TISSUE-SECTIONS

C-reactive protein (CRP) is a well-known serum protein which increases during inflammation and deposits in destructed tissues. To establish whether CRP appears in brain of Alzheimer's disease (AD), we immunohis tochemically investigated tissue sections which were pretreated with f ormic acid. Positive immunostainings by anti-CRP antibodies were clear ly recognized in senile plaques (SP) in the pretreated tissue sections whereas very weak immunostainings in non-treated sections. These find ings may suggest that the formation process of SP contains an acute ph ase of inflammatory state.