LACK OF EFFECT OF ANTIPSYCHOTIC AND ANTIDEPRESSANT DRUGS ON GLUTAMATE-RECEPTOR MESSENGER-RNA LEVELS IN RAT BRAINS

Authors
ORETTI RG SPURLOCK G BUCKLAND PR MCGUFFIN P
Citation
Rg. Oretti et al., LACK OF EFFECT OF ANTIPSYCHOTIC AND ANTIDEPRESSANT DRUGS ON GLUTAMATE-RECEPTOR MESSENGER-RNA LEVELS IN RAT BRAINS, Neuroscience letters, 177(1-2), 1994, pp. 39-43
Citations number
26
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
177
Issue
1-2
Year of publication
1994
Pages
39 - 43
Database
ISI
SICI code
0304-3940(1994)177:1-2<39:LOEOAA>2.0.ZU;2-I
Abstract
By employing multiprobe oligonucleotide solution hybridisation (MOSH) we have measured the levels of mRNA encoding the NMDA receptor subtype s (R1. R2A, R2B and R2C) and the non-NMDA glutamate receptor subtypes (GluR1, 2, 3, and 4) within rat brain following, 1-32 days of antipsyc hotic or antidepressant drug administration. The results suggest that the drugs studied do not significantly alter rat glutamatergic system mRNA levels when compared to controls.