Rg. Oretti et al., LACK OF EFFECT OF ANTIPSYCHOTIC AND ANTIDEPRESSANT DRUGS ON GLUTAMATE-RECEPTOR MESSENGER-RNA LEVELS IN RAT BRAINS, Neuroscience letters, 177(1-2), 1994, pp. 39-43
By employing multiprobe oligonucleotide solution hybridisation (MOSH)
we have measured the levels of mRNA encoding the NMDA receptor subtype
s (R1. R2A, R2B and R2C) and the non-NMDA glutamate receptor subtypes
(GluR1, 2, 3, and 4) within rat brain following, 1-32 days of antipsyc
hotic or antidepressant drug administration. The results suggest that
the drugs studied do not significantly alter rat glutamatergic system
mRNA levels when compared to controls.