HUMAN CORTICAL NEURONAL (HCN) CELL-LINES - A MODEL FOR AMYLOID-BETA NEUROTOXICITY

Authors
ZHANG ZY DRZEWIECKI GJ HOM JT MAY PC HYSLOP PA
Citation
Zy. Zhang et al., HUMAN CORTICAL NEURONAL (HCN) CELL-LINES - A MODEL FOR AMYLOID-BETA NEUROTOXICITY, Neuroscience letters, 177(1-2), 1994, pp. 162-164
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
177
Issue
1-2
Year of publication
1994
Pages
162 - 164
Database
ISI
SICI code
0304-3940(1994)177:1-2<162:HCN(C->2.0.ZU;2-#
Abstract
Human cortical neuronal cell lints HCN-1A and HCN-2 are killed followi ng exposure of the differentiated cells to amyloid beta-peptide(1-40), a component of senile plaques and other amyloid deposits in brains fr om Alzheimer's patients. We present a model of A beta toxicity uncompl icated by the presence of other cell types that can be used to address the mechanism of A beta neurotoxicity. This model will be useful in t he evaluation of neuroprotective compounds which may attenuate cortica l neuronal loss in Alzheimer's disease.