Twenty patients, scheduled for surgical resection of thoracoabdominal
aortic aneurysm were divided into two groups according to the type of
differential lung ventilation used during graft replacement of the des
cending thoracic aorta. In the high-frequency jet ventilation (HFJV) g
roup of ten patients, HFJV was applied to the left lung once collapsed
and retracted by the surgeon, the patient lying in the right lateral
decubitus and being intubated by a Carlens' tube. In the continuous po
sitive airway pressure (CPAP) group of ten patients, CPAP was applied
to the left lung at the same mean airway pressure as HFJV (1 kPa). Bef
ore anaesthetic induction, an arterial and a Swan-Ganz catheter were i
nserted for cardiovascular monitoring. The same anaesthetic technique
using Fentanyl 6 mu g.kg(-1), flunitrazepam 0.02 mg.kg(-1) and pancuro
nium 0.1 mg.kg(-1) was used for each patient. Haemodynamic and respira
tory measurements were made: 15 min after positioning the patients in
the light lateral decubitus using two-lung ventilation; 15 min after c
ollapse and retraction of the left lung using one-lung ventilation and
15 min after using differential lung ventilation with CPAP or HFJV. L
eft lung collapse with conventional one-lung ventilation induced a dra
matic decrease in arterial oxygenation: Pao(2)/Fio(2) ratio decreased
from 43 +/- 6 kPa to 20 +/- 8 kPa, alveolo-arterial oxygen difference
increased from 24 +/- 7 kPa to 72 +/- 11 kPa and pulmonary shunt incre
ased from 17 +/- 2% to 37 +/- 3%. Whereas differential lung ventilatio
n with CPAP did not improve any of the respiratory parameters measured
, differential lung ventilation with HFJV, significantly increased Pao
(2)/Fio(2) ratio to 41 +/- 14 kPa. Therefore, since HFJV improves gas
exchange without altering the conditions of surgical comfort, differen
t lung ventilation with HFJV appears to be superior to differential lu
ng ventilation with CPAP.