Su. Song et al., AN ENV-LIKE PROTEIN ENCODED BY A DROSOPHILA RETROELEMENT - EVIDENCE THAT GYPSY IS AN INFECTIOUS RETROVIRUS, Genes & development, 8(17), 1994, pp. 2046-2057
The gypsy element of Drosophila differs from most LTR retrotransposons
in containing a third open reading frame that resembles retroviral en
v genes. The protein encoded by ORF3 is glycosylated and processed, li
ke all retroviral envelope proteins. The protein is expressed at high
levels in fly strains in which gypsy elements are active. In these str
ains the protein is found primarily in viral particles. When larvae of
fly strains in which gypsy is normally inactive are exposed to sucros
e gradient fractions containing these particles, a high level of gypsy
insertion activity is observed in their progeny. Thus, gypsy has the
expected properties of an insect retrovirus.