BRAIN GLUCOSE-METABOLISM IN ALZHEIMERS-DISEASE

Authors
SWERDLOW R MARCUS DL LANDMAN J KOOBY D FREY W FREEDMAN ML
Citation
R. Swerdlow et al., BRAIN GLUCOSE-METABOLISM IN ALZHEIMERS-DISEASE, The American journal of the medical sciences, 308(3), 1994, pp. 141-144
Citations number
30
Categorie Soggetti
Medicine, General & Internal
Journal title
The American journal of the medical sciences → ACNP
ISSN journal
00029629
Volume
308
Issue
3
Year of publication
1994
Pages
141 - 144
Database
ISI
SICI code
0002-9629(1994)308:3<141:BGIA>2.0.ZU;2-G
Abstract
In vitro determination of brain glucose metabolism in the temporal cor tex from patients with Alzheimer's disease showed a marked decrease wh en compared with nondemented, age-matched control subjects. Additional determinations on normal human temporal cortex obtained at autopsy de monstrated an age-dependent decline in the rate of glucose use. These data provide an in vitro correlate for positron emission tomography st udies that suggest decreased brain glucose use in Alzheimer's disease.