CONDENSED AS-TRIAZINES - SYNTHESIS OF IMIDAZO[4,5-E]-AS-TRIAZINE 1-OXIDES (6-AZAPURINE 6-OXIDES) AS GUANINE AND HYPOXANTHINE ANALOGS

Imidazo[4,5-e]-as-triazine 1-oxides (6-azapurine 6-oxides), structural ly related to guanine and hypoxanthine, have been prepared. Reaction o f 5,6-diamino-3-methylsulfonyl-as-triazine 1-oxide(1) with hydrazine a fforded 5,6-diamino-3-hydrazino-as-triazine 1-oxide(2) which was then oxidized with mercuric oxide to give 5,6-diamino-as-triazinel-oxide(3) . The 3-methylsulfonyl group of 1 was also replaced with liquid ammoni a and methanolic ammonia respectively to give 3-amino (5) and 3-methox y (6) derivatives. as-Triazine N-oxides were then cyclized with trieth yl orthoformate (TEOF) to afford the title compounds.