CYCLOPHILIN-A AND AN ANTIBODY AGAINST CYCLOSPORINE-A RESEMBLE EACH OTHER IN THEIR BINDING-SITES

Authors
DENESYUK AI LUNDELL J ZAVYALOV VP KORPELA T
Citation
Ai. Denesyuk et al., CYCLOPHILIN-A AND AN ANTIBODY AGAINST CYCLOSPORINE-A RESEMBLE EACH OTHER IN THEIR BINDING-SITES, Immunology letters, 41(2-3), 1994, pp. 213-216
Citations number
12
Categorie Soggetti
Immunology
Journal title
Immunology letters → ACNP
ISSN journal
01652478
Volume
41
Issue
2-3
Year of publication
1994
Pages
213 - 216
Database
ISI
SICI code
0165-2478(1994)41:2-3<213:CAAAAC>2.0.ZU;2-O
Abstract
The three-dimensional structures of cyclosporin A complexed with cyclo philin A or Fab fragment of a monoclonal antibody were compared. In th ese two complexes conformations of the fragment D-alanine-8-N-methylva line11 in cyclosporin A were in a good agreement. In addition, cycloph ilin A and the Fab fragment had related arrangements of the aromatic a mino acids in their binding sites, implying that antibody independentl y utilizes similar structural themes for binding cyclosporin A as cycl ophilin A.