DIAGNOSTIC AND PROGNOSTIC IMPORTANCE OF CHROMOSOMAL-ABERRATIONS IDENTIFIED IN 61 DOGS WITH LYMPHOSARCOMA

To determine the diagnostic and/or prognostic importance of chromosoma l aberrations identified in dogs with malignant (non-Hodgkin's) lympho ma, clinical stages for 61 dogs with lymphosarcoma were determined, th e lymph node(s) were histopathologically graded, and the malignant tis sue lymphocytes were karyotyped. The results from life table survival curve analysis demonstrated that first remission length and survival t ime were significantly longer in 15 of 61 (25%) dogs that had a trisom y of chromosome 13 as the primary chromosomal aberration than in those dogs (46/61, 75%) with other primary chromosomal aberrations (P < 0.0 5). Sex, age, weight, histopathologic subtype and grade, World Health Organization (WHO) clinical stage, WHO and modified Karnofsky performa nce status, chromosomal modal number, and treatment protocol were of n o prognostic importance in predicting first remission length or surviv al time (P > 0.05). Multivariate analysis did not identify a significa nt correlation between the prognostic groups or within the various pro gnostic subsets (P > 0.05). The pathogenesis of canine and human non-H odgkin's lymphoma, as observed cytogenetically, differs.