PERCUTANEOUS PENETRATION IN-VIVO OF AMINO-ACIDS

An alternative analytical methodology has been developed to evaluate t he in vivo percutaneous penetration of non-radioactive compounds in hu man stratum corneum by the stripping technique. Different amino acids were applied and even though a slight influence of their structure was found on percutaneous penetration, some topical application strategie s such as vehicles, skin preparation and evaporation conditions were c onsidered to be important for skin permeation. The amino acid amount f ound in the stratum corneum could probably be sufficient to express it s moisturizing action.