K. Abe et al., SPINAL-CORD BLOOD-FLOW DURING PROSTAGLANDIN E(1) INDUCED HYPOTENSION, Prostaglandins, leukotrienes and essential fatty acids, 51(3), 1994, pp. 173-176
To evaluate the effect of prostaglandin E(1) (PGE(1)) induced hypotens
ion on spinal blood flow (SBF) during spinal surgery, SBF was measured
under isoflurane anaesthesia by the heat clearance method in 10 patie
nts with spinal tumour. An initial dose of 0.1 mu g/kg/min of PGE(1) w
as administered intravenously after spinal opening and the dose was ad
justed to maintain the mean arterial blood pressure (MAP) at about 60
mmHg. PGE(1) was discontinued at the completion of the operative produ
ces. After starting PGE(1), MAP and rate pressure product (RPP) decrea
sed significantly compared with preinfusion values (P < 0.01), and the
hypotensive effect of PGE(1) remained constant at 60 min after its di
scontinuation. Heart rate (HR) did not change throughout the study. SB
F showed no change over the course of PGE(1) induced hypotension (prei
nfusion : 47.8 +/- 21.7 ml/100 g/min, at 15 min : 41.2 +/- 16.9 ml/100
g/min, at 30 min : 40.4 +/- 16.8 ml/100 gl min, and at 60 min : 46.1
+/- 16.3 ml/100 g/min, respectively). These results suggest that PGE(1
) may be a useful drug for hypotensive anaesthesia in surgery for spin
al cord tumours because PGE(1) maintained SBF.