SYNTHESIS, MECHANISM OF ACTION, AND QSAR OF HERBICIDAL 3-SUBSTITUTED-2-ARYL-4,5,6,7-TETRAHYDROINDAZOLES

Authors
LYGA JW PATERA RM PLUMMER MJ HALLING BP YUHAS DA
Citation
Jw. Lyga et al., SYNTHESIS, MECHANISM OF ACTION, AND QSAR OF HERBICIDAL 3-SUBSTITUTED-2-ARYL-4,5,6,7-TETRAHYDROINDAZOLES, Pesticide science, 42(1), 1994, pp. 29-36
Citations number
31
Categorie Soggetti
Agriculture
Journal title
Pesticide science → ACNP
ISSN journal
0031613X
Volume
42
Issue
1
Year of publication
1994
Pages
29 - 36
Database
ISI
SICI code
0031-613X(1994)42:1<29:SMOAAQ>2.0.ZU;2-5
Abstract
A factorially designed set of 3-substituted 2-aryl-4,5,6,7-tetrahydro- indazoles was synthesized and their herbicidal properties were evaluat ed using regression analysis. For optimal activity, the substituent at position 3 should be neither strongly hydrophobic nor hydrophilic and should have a small minimum radius. A study of the mechanism of actio n indicated that the tetrahydroindazoles are inhibitors of the enzyme protoporphyrinogen oxidase.