While most patients with recognized depressive illness are treated by
general practitioners without referral, there is evidence that many pa
tients classifiable as depressed after psychiatric interview are not d
iagnosed as such. Missing depression is of great importance since it i
s now eminently treatable. This paper explores the use in primary care
of questionnaire tests for depression and also their role in case fin
ding in vulnerable groups of patients. The potential of existing valid
ated questionnaires in clinical work and audit is largely unexploited.
As yet, however, there is no gold standard for the diagnosis of depre
ssion seen in primary care. Clusters of symptoms do not yet accurately
predict the course of the illness or response to treatment. More rese
arch is needed on the natural history of depression seen in the commun
ity, as well as on treatment and outcome.