CARDIOVASCULAR APPLICATIONS OF FLUOROCARBONS - CURRENT STATUS AND FUTURE-DIRECTION - A CRITICAL CLINICAL APPRAISAL

Authors
Citation
Jd. Ogilby, CARDIOVASCULAR APPLICATIONS OF FLUOROCARBONS - CURRENT STATUS AND FUTURE-DIRECTION - A CRITICAL CLINICAL APPRAISAL, Artificial cells, blood substitutes, and immobilization biotechnology, 22(4), 1994, pp. 1083-1096
Citations number
35
Categorie Soggetti
Engineering, Biomedical","Materials Science, Biomaterials
ISSN journal
10731199
Volume
22
Issue
4
Year of publication
1994
Pages
1083 - 1096
Database
ISI
SICI code
1073-1199(1994)22:4<1083:CAOF-C>2.0.ZU;2-G
Abstract
Alteration of normal blood now to the heart may result in myocardial i schemia or infarction. Perfluorochemical emulsions offer a potential m eans to improve oxygenation of the heart during periods of hypoxia. Th e small particle size and linear disassociation curve of perfluorochem icals may result in greater oxygen delivery than blood particularly in severely diseased or damaged atherosclerotic vessels. Intracoronary F luosol given during PTCA reduces the myocardial ischemia which occurs during balloon inflation. Although Fluosol does not prevent myocardial dysfunction during prolonged balloon inflations, new concentrated per fluorochemicals have increased oxygen delivery capacity and may have g reater benefit. Experimentally, during coronary occlusions, perfluoroc hemicals promote higher oxygen tension in areas of ischemia and result in infarct size reduction. Reduction of oxygen free radicals has been proposed as the mechanism by which Fluosol exerts its ability to redu ce infarct size. Clinical studies with Fluosol and thrombolytic therap y for treatment of acute myocardial infarctions are ongoing to assess ability to preserve myocardial function. Perfluorochemical cardioplegi a can deliver oxygen during periods of cardiac arrest and may improve immediate post CPB myocardial function particularly in those patients with pre-existing left ventricular dysfunction. The oxygen-carrying ca pacity of perfluorocarbons and its unique properties offer great advan tages to improve the treatment of cardiovascular diseases.