TUMOR OXYGEN-TENSION - MEASUREMENT USING OXYGENT(TM) AS A F-19 NMR PROBE AT 4.7 T

Authors
MASON RP ANTICH PP
Citation
Rp. Mason et Pp. Antich, TUMOR OXYGEN-TENSION - MEASUREMENT USING OXYGENT(TM) AS A F-19 NMR PROBE AT 4.7 T, Artificial cells, blood substitutes, and immobilization biotechnology, 22(4), 1994, pp. 1361-1367
Citations number
10
Categorie Soggetti
Engineering, Biomedical","Materials Science, Biomaterials
Journal title
Artificial cells, blood substitutes, and immobilization biotechnology → ACNP
ISSN journal
10731199
Volume
22
Issue
4
Year of publication
1994
Pages
1361 - 1367
Database
ISI
SICI code
1073-1199(1994)22:4<1361:TO-MUO>2.0.ZU;2-A
Abstract
We have used Oxygent(TM) (an emulsion of perflubron [PFOB]) to measure pO(2) in a Dunning prostatic adenocarcinoma non-invasively using F-19 NMR spectroscopy. We have confirmed a linear relationship between the spin-lattice relaxation rate (R(1)) and pO(2) and we have assessed th e effect of temperature. R(1) of the individual resonances of Oxygent is considerably more sensitive to changes in pO(2) than other PFC emul sions, whilst being considerably less sensitive to interference from t emperature variation. Oxygent has two well resolved resonances (Delta delta similar to 18ppm) and these were both exploited to estimate tumo r pO(2)=47+/-5 torr.