FLUORINATED PHOSPHOLIPID-BASED VESICLES AS POTENTIAL-DRUG CARRIERS - ENCAPSULATION SUSTAINING OF DRUGS AND STABILITY IN HUMAN SERUM/

Authors
FREZARD F SANTAELLA C VIERLING P RIESS JG
Citation
F. Frezard et al., FLUORINATED PHOSPHOLIPID-BASED VESICLES AS POTENTIAL-DRUG CARRIERS - ENCAPSULATION SUSTAINING OF DRUGS AND STABILITY IN HUMAN SERUM/, Artificial cells, blood substitutes, and immobilization biotechnology, 22(4), 1994, pp. 1403-1408
Citations number
6
Categorie Soggetti
Engineering, Biomedical","Materials Science, Biomaterials
Journal title
Artificial cells, blood substitutes, and immobilization biotechnology → ACNP
ISSN journal
10731199
Volume
22
Issue
4
Year of publication
1994
Pages
1403 - 1408
Database
ISI
SICI code
1073-1199(1994)22:4<1403:FPVAPC>2.0.ZU;2-7
Abstract
The release of entrapped 5(6)-carboxyfluorescein from fluorinated vesi cles in a buffer or in human serum is considerably less than that from hydrogenated liposomes. The presence of a fluorinated core inside the liposomal membrane definitely reduces its permeability. In some cases , the stability of liposomes made from fluorinated phospholipids alone is better than that of egg phosphatidylcholine cholesterol 1/1 vesicl es, which are among the least permeable and most stable hydrogenated l iposomes.