IS THERE A LONG-LASTING EFFECT OF A SHORT-TERM NERVE GROWTH-FACTOR APPLICATION ON AXOTOMIZED RAT SEPTOHIPPOCAMPAL NEURONS

Authors
NAUMANN T KERMER P SEYDEWITZ V ORTMANN R DAMATO F FROTSCHER M
Citation
T. Naumann et al., IS THERE A LONG-LASTING EFFECT OF A SHORT-TERM NERVE GROWTH-FACTOR APPLICATION ON AXOTOMIZED RAT SEPTOHIPPOCAMPAL NEURONS, Neuroscience letters, 173(1-2), 1994, pp. 213-215
Citations number
27
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
173
Issue
1-2
Year of publication
1994
Pages
213 - 215
Database
ISI
SICI code
0304-3940(1994)173:1-2<213:ITALEO>2.0.ZU;2-J
Abstract
Loss of choline acetyltransferase (ChAT)-immunoreactive neurons in the medial septum (MS) following fimbria transection can be prevented by nerve growth factor (NGF) application. Here we have studied the long-t erm effects of a short-term NGF treatment starting immediately after l esion and lasting for the first 3 weeks. We demonstrate that this NGF treatment rescues many ChAT neurons after short survival time (3 weeks ) but does not have a long-lasting (6 months) effect on both ChAT- and parvalbumin-immunopositive (GABAergic) MS neurons.