HISTOLOGICAL-EVALUATION OF BENIGN PROSTATIC HYPERPLASIA TREATED BY LONG-TERM ADMINISTRATION OF CHLORMADINONE ACETATE (CMA)

Although the clinical effects of attempted nonsurgical treatment of be nign prostatic hyperplasia have been well documented, detailed histolo gical evaluation of the effects of treatment appears to be limited. Th e effect of long-term administration of an antiandrogen, chlormadinone acetate (CMA), on benign prostatic hyperplasia was evaluated with his tological comparison of two biopsy specimens, one before treatment and one after treatment. Secretory epithelium showed obvious regressive c hanges with occasional basal cell prominence after CMA treatment. Stro mal elements, however, did not show any marked changes, except for occ asional edematous loosening. Scores of multiple epithelial parameters tended to be correlated with clinical improvement in urinary obstructi ve symptoms, especially in patients with predominant glandular hyperpl asia. These results suggest that long-term administration of the poten t antiandrogen CMA to inhibit dihydrotestosterone-receptor binding mig ht be a useful therapeutic maneuver in patients with glandular hyperpl asia, without any deterioration of the stromal component. (C) 1994 Wil ey-Liss, Inc.