COMPARISON OF AMINOGLYCOSIDE PHARMACOKINETICS IN ASIAN, HISPANIC, ANDCAUCASIAN PATIENTS BY USING POPULATION PHARMACOKINETIC METHODS

A population pharmacokinetic model for aminoglycosides was developed f rom 24 Hispanic, 16 Asian, and 22 Caucasian patients. A nonparametric expectation maximization algorithm for population modeling was used. W ith this one-compartment model, the parameters were the slope of the a pparent volume of distribution versus weight (VS) and the slope of the elimination rate constant versus the creatinine clearance rate (KS). The mean VS (+/- standard deviation) was not different at 0.264 (+/- 0 .05), 0.248 (+/- 0.055), and 0.260 (+/- 0.080) liter/kg of body weight for Asian, Hispanic, and Caucasian populations, respectively (P > 0.1 0). The KS means +/- standard deviations,were 0.00424 +/- 0.00129, 0.0 0404 +/- 0.00160 and 0.00394 0.00103 [h(ml/min/1.73 m(2))](-1) +/- for Hispanic, Asian, and Caucasian populations, respectively. Again, ther e was no statistical difference among the groups (P > 0.10). In conclu sion, there are no differences in aminoglycoside pharmacokinetics amon g Asian, Hispanic, and Caucasian patients.