EXPRESSION OF MHC CLASS-I ANTIGEN IN MORRIS RAT HEPATOMA AND NORMAL LIVER

Expression of major histocompatibility complex (MHC) class I antigen i n Morris rat;hepatoma 7777 and normal rat liver tissues was studied by immunohistochemical techniques, Western blot and radiobinding assay. It was found that hepatoma tissue displayed a pattern of enhanced MHC class I antigen expression compared with normal liver. This phenomenon may represent an uncommon pattern of MHC class I antigen expression o f liver tumor. The influence of enhanced MHC class I antigen expressio n on the development and spread of tumors as well as the possible mech anisms of this enhancement are discussed.