THE CHEMISTRY OF PSEUDOMONIC ACID .13. MODIFICATIONS AT C-12 TO C-14

Authors
FORREST AK OHANLON PJ WALKER G
Citation
Ak. Forrest et al., THE CHEMISTRY OF PSEUDOMONIC ACID .13. MODIFICATIONS AT C-12 TO C-14, Tetrahedron, 50(36), 1994, pp. 10739-10748
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
36
Year of publication
1994
Pages
10739 - 10748
Database
ISI
SICI code
0040-4020(1994)50:36<10739:TCOPA.>2.0.ZU;2-9
Abstract
The novel antibiotic, pseudomonic acid, binds tightly to its target en zyme, isoleucyl t-RNA synthetase. The C12 to C14 region of the molecul e is though to bind to the isoleucine binding site of the enzyme. Semi synthetic analogues in which functionality present in this region have been systematically modified are reported here: all the derivatives p repared showed weak enzyme binding.