INTRAMOLECULAR AMIDOALKYLATION OF AROMATICS .3. SYNTHESIS OF CONFORMATIONALLY RESTRICTED BRIDGED PEPTIDE ANALOGS OF PHE-GLY

Authors
RABIBARAKAY A BENISHAI D
Citation
A. Rabibarakay et D. Benishai, INTRAMOLECULAR AMIDOALKYLATION OF AROMATICS .3. SYNTHESIS OF CONFORMATIONALLY RESTRICTED BRIDGED PEPTIDE ANALOGS OF PHE-GLY, Tetrahedron, 50(36), 1994, pp. 10771-10782
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
36
Year of publication
1994
Pages
10771 - 10782
Database
ISI
SICI code
0040-4020(1994)50:36<10771:IAOA.S>2.0.ZU;2-S
Abstract
Derivatives of the Phe-alpha-methoxyglycine (4) were prepared and foun d to undergo stereospecific intramolecular amidoalkylation to give der ivatives of 4-amino-2-benzazepin-3-one-1-carboxylic acid 5 (ABZC). The cyclic compounds 5a-g are conformationally restricted peptides contai ning a bridged Phe-Gly moiety.