SULFASALAZINE INDUCED TOXIC DRUG ERUPTION - PUSTULAR ERYTHRODERMA ANDPSEUDOLYMPHOMATOUS SYNDROME - 2 CASES

We report two observations of drug eruption due to salazosulfapyridine which occurred 15 to 21 days after introducing the molecule. The two patients were of Carabian origin and presented with fever, erythroderm ia which became pustular and a pseudolymphomatous syndrome. Favourable outcome was observed 4 to 6 weeks later. The diagnosis of toxidermia was made based on the strong imputability of salazosulfapyridine in bo th cases. Severe immunoallergic reactions to this molecule have been d escribed, including fatal cytolytic hepatitis and Lyell syndrome.