Acute respiratory failure in patients with COPD is a common cause of e
mergent medical intervention and can be difficult to assess and manage
. Assessment is complicated by the imposition of acute respiratory fai
lure on chronic respiratory failure and by the large number of problem
s that can tip a carefully compensated patient with COPD toward acute
respiratory failure. Management must include correcting life-threateni
ng hypoxemia and life-threatening acidosis, treating the underlying di
sease processes, and preventing and treating complications. Management
can be enhanced by an understanding of the prognosis of acute respira
tory failure in COPD and by incorporation of some ethical and societal
issues.