Severe pneumonia can be acquired by previously healthy patients, those
with pre-existing illness, or those hospitalized for an unrelated ill
ness. Because diagnosis is frequently difficult or delayed, treatment
is usually empirically tailored to the most probable offending organis
ms and the patient's condition. This article reviews the pathogenesis
of community and hospital-acquired pneumonia, clinical features, and d
iagnostic techniques. An approach to selecting an antibiotic regimen i
s suggested.