INABILITY TO REMEMBER AND AMNESIA - RECEP TOR MECHANISMS AND BRAIN MAPPING

Inability to remember and amnesia have been shown to be active neuroch emical processes. The coupled processes (blockade of the trigerring DA stimulating system and activation of the inhibitory GABA-ergic system with the predominant value of postsynaptic D-2 receptors) are a neuro chemical basis for development of amnesia. The mechanism of spontaneou s forgetting is provided by a decrease in the activity of the dopamine rgic system along with the enhancement of benzodiazepine-GABA-ergic in terferentional inhibition. The observed changes in dopamine metabolism , para-tyramine appearance, as well as restructure of D-2 receptors pr ovide the activity of dopamine increasing mechanism which determines t he retention of memory traces. A computer model of the spatial interac tion of the dopamine membrane-receptor complex was constructed by scan ning the samples of synaptic membranes after learning and amnesia. A n ew method of inducing psychogenic amnesia in human beings has been ela borated. Amnesia is characterized by the absence of increases in the n umber of cortical connections reflecting the emotional factor of infor mation.